Endocrine Abstracts

Introduction: Diabetic nephropathy is a major complication of diabetes mellitus. Involvement of abnormal nitric oxide (NO) production, both via nitric oxide synthase (NOS) dependent and independent pathways (for example, xantine oxoridoreductase (XOR)) has been discussed. New compounds to treat diabetic nephropathy are searched intensively, some novel dihydropirine class drugs (DHP) have been proposed for this purpose.Aim: To study the changes in NO conc...

Introduction: A possible involvement of proteasomes in the pathogenesis of type II diabetes mellitus has been recently reported. Therefore, association of polymorphism of proteosomal genes with type II diabetes mellitus is of particular interest. In this study, molecular markers of the proteasomal alpha subunit 6 gene PSMA6 and its adjacent genomic sites have been analyzed.The goal of this study was to characterize polymorphisms of the HSMS801, HSMS702, ...

Background: Hypoxia, oxidative stress and inflammation induced by hyperglycaemia are ‘key players’ in development of diabetic complications.Aim: To analyze differences in levels of nitric oxide (NO) and its metabolites nitrate and nitrite (NO2/NO3) and well as angiopoietin 2 (Ang2) and neuropeptide Y (NPY) in patients with type 1 diabetes and different complications status; to analyze associations between these markers.Me...

Background and aim: We carried out a prospective 1-year study to examine the association of sudomotor dysfunction with mortality in patients with chronic kidney disease.Materials and methods: 97 patients from dialysis unit (28 with diabetic nephropathy (DN); 37 with nephroangiosclerosis, (NA), 18 with glomerulonephritis (GN), 14 with other conditions (O)); 32 with type 2 DM and creatinine clearance (CrCl) 30–50 ml/min; and 24 transplanted patients w...

Rheumatoid arthritis (RA) is known to be associated with cardiovascular comorbidity. In particular, patients with RA are known to be at increased for the development of atherosclerosis. Treatment with biological agents in RA may affect lipid levels.Aim: The aim was to study the effect of rituximab treatment on lipid levels in RA patients.Methods: In a cohort of 20 patients with RA lipid levels were studied before, 6 and 12 months a...

Although bilateral inferior petrosal sinus sampling (BIPSS) is the most accurate procedure for the differential diagnosis of ACTH-dependent Cushing’s syndrome, a false-negative rate of 4–15% has been reported. An even lower sensitivity has been shown in patients with equivocal responses to CRH and/or high-dose dexamethasone suppression test (HDST). In the present study we investigated whether the administration of CRH plus desmopressin (DDAVP) during BIPPS, which is ...

Background: Gastrointestinal (GI) neuroendocrine tumours (NETs) are potentially malignant lesions originating from the enterochromaffin cells of the GI tract. These neoplasms often produce characteristic hormonal syndromes and can cause debilitating symptoms. Endoscopic submucosal dissection (ESD) is a well-established, complex, endoscopic technique, which allows for full resection of the mucosal and submucosal lesions without the need for open surgery.M...

Background: Although small bowel (SB) neuroendocrine tumours (SBNETs) often present as indolent lesions, late diagnosis may result in poor outcomes. Successful management is therefore dependent on early identification. Double-balloon enteroscopy (DBE) enables direct SB mucosal visualisation, sampling and endotherapy. Our aim was to evaluate the role of DBE for early diagnosis and management of SBNETs.Methods: Retrospective review of all SBNETs diagnosed/...

Background: Diabetic ketoacidosis (DKA) has been associated with severe hemolysis in patients with Glucose-6-phosphate dehydrogenase (G6PD) deficiency after restoration of euglycemia. Less than 30 cases have been reported so far. The exact mechanism is not fully understood.Case presentation: A 35-year-old African American man presented to the emergency department with polyuria, polydipsia, abdominal pain and weight loss the last 15 days. Physical examina...

Background: Both surgical and spontaneous menopause are associated with increased cardiovascular disease (CVD) risk. Recent evidence reported that clusters of menopausal symptoms are associated with accumulation of cardiometabolic risk factors. Climacteric symptoms are also known to be affected by lifestyle parameters, ethnicity, the geographical location as well as by the overall health status at the time of the menopausal transition.Aim: This study aim...